Selenophosphate Synthetase (SPS)
At least two forms of selenophosphate synthetase have been identified in the body.
One form (called SPS1) does not contain selenocysteine and is thought to recycle selenuim from selenocysteine.
The SPS2 isoform, which contains selenocysteine, catalyzes thr synthesis of selenophosphate from selenide, as shown here:
Selenophosphate synthetase
H2Se-------------------------------------------------> HSePO2-3
Selenide ATP---------------> AMP + Pi Selenophosphate
Selenophosphate is a key compound needed in the body to synthesize other selenocysteine-containing proteins or enzymes such as glutathione peroxidase, deiodinase, thioredoxin reductase, selenoprotein P, and others.
At least two forms of selenophosphate synthetase have been identified in the body.
One form (called SPS1) does not contain selenocysteine and is thought to recycle selenuim from selenocysteine.
The SPS2 isoform, which contains selenocysteine, catalyzes thr synthesis of selenophosphate from selenide, as shown here:
Selenophosphate synthetase
H2Se-------------------------------------------------> HSePO2-3
Selenide ATP---------------> AMP + Pi Selenophosphate
Selenophosphate is a key compound needed in the body to synthesize other selenocysteine-containing proteins or enzymes such as glutathione peroxidase, deiodinase, thioredoxin reductase, selenoprotein P, and others.
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